Yeast: A Potential Vaccine Delivery Carrier
Keywords:
yeast, vaccine, recombinant, oral sub mucous fibrosis , immune response, proteins, genesAbstract
Yeasts are genetically tractable, and they share many features with humans. They represents a potential carrier for the delivery of drugs, proteins and genes for the treatment of various disease and disorders. Yeast offers various advantages such as rapid growth rate, inexpensive, easy availability, minimum growth requirements, allows genetic modification, non- immunogenic, natural adjuvant and well defined fermentation technology which makes them a suitable model for development of vaccines. The specific cellular characteristics possed by yeast makes them resistant to gastro-intestinal enviormnent and allows passage through the gastro-intestinal membrane, enabling them to be a potential carrier for oral vaccines. In this review, we seek to outline the beneficial role of yeast using its recombinant modification with supporting evidence to achieve effective vaccine delivery in stimulating and
modulating the immune response in the host. In addition, the efficacy of yeast based carrier for oral vaccines is also highlighted.
Downloads
Downloads
Published
Issue
Section
License
Copyright (c) 2023 V.C. Patole, J.G. Mahore, S.S. Deshkar, S. Shekade, A. Gutte (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright and Licensing
All articles published in Trends in Biomaterials and Artificial Organs are published Open Access. To ensure the widest possible dissemination of research while protecting the integrity of the original work, we utilize the Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) 4.0 International License.
User Rights
Under this license, the public is free to share (copy and redistribute the material in any medium or format) under the following terms:
- Attribution: Users must give appropriate credit, provide a link to the license, and indicate if changes were made.
- Non-Commercial: Users may not use the material for commercial purposes. This includes, but is not limited to, the sale of the article or its use in promotional materials for-profit.
- No Derivatives: If a user remixes, transforms, or builds upon the material, they may not distribute the modified material.
Author Rights
Authors retain copyright of their work while granting the journal a non-exclusive license to publish. Because of the NoDerivs (ND) and Non-Commercial (NC) designations:
- Third parties (such as other researchers) must seek permission from the authors/journal to include figures, tables, or portions of the text in new works or commercial publications.
- Authors may deposit the "Version of Record" in institutional repositories immediately upon publication, provided the CC BY-NC-ND 4.0 license is clearly linked.
