Nanoparticles in Regenerative Endodontics: A Current Status Review

Abstract

Nanotechnology has significantly evolved in the past few decades, compelling several possible applications in various biomedical fields. There have been noteworthy developments seen in the nanoparticles’ utilization in endodontics due to their unique nanoscale dimensions, generating remarkable interest in dentistry. They hold many divergent properties that may augment the endodontic infection’s treatment, such as enhanced reactivity and antibacterial activity, and their ability to be functionalized with other reactive compounds. In the search for the “ideal” material, there have been innumerable experimental research on materials incorporated with nanoparticles and devices coated with the same. Nanoparticles’ use in the field of regenerative endodontics shows a very promising prospect as they are known for bioactive molecule’s release support system and amplifying the scaffold’s biophysical properties. Applying nano-scaffolds for pulp regeneration is another use of nanotechnology in endodontics that created a stirring development in the reconstruction of pulp structure. The persistently expanding research in this area has led to an enormous prospective of nanoparticle’s translational applications in regenerative endodontics. This review article aims to study the application of nanoparticles in different stages of regenerative endodontic therapy and provide an overview of its current advancement.