Synergistic Effect of Quercus incana Fruit Extract Incorporated Chitosan in Accelerating Wound Healing and Inflammation Reduction

Authors

  • Pavan Vijay Kartik School of Biosciences and Technology, Vellore Institute of Technology, VIT University, Vellore 632014, Tamilnadu, India Author
  • R. Mathan Rajan Department of Conservative Dentistry & Endodontics, Sri Ramachandra Dental College, Sri Ramachandra Institute of Higher Education and Research, Chennai 600 116, Tamilnadu, India Author
  • K. Manigandan Department of Conservative Dentistry & Endodontics, Sri Ramachandra Dental College, Sri Ramachandra Institute of Higher Education and Research, Chennai 600 116, Tamilnadu, India Author
  • Pratibha Ramani Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India Author
  • Ramya Ramadoss Department of Oral Biology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India Author
  • Saheb Ali Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India Author
  • Radha Gosala Department of Oral Biology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India Author

Keywords:

chitosan, contact angle, anti-inflammatory, wound healing, gene expression

Abstract

This study investigates the wound healing and skin allergy applications of Quercus incana (QI) fruit extract incorporated with chitosan (CS) using a freeze-drying method. The extract was prepared by aqueous extraction and combined with CS to enhance its therapeutic properties. The formulation was characterized using Fourier-transform infrared spectroscopy to confirm the interaction between the QI extract and CS. The contact angle study revealed the surface wettability of the composite material. Anti-inflammatory assays demonstrated that QI-CS outperformed CS in reducing inflammation, likely due to the synergistic effects of the bioactive phenolic compounds from QI, which inhibit pro-inflammatory cytokines. Histopathological analysis of zebrafish wound healing indicated superior tissue regeneration and reduced inflammation in QI-CS-treated groups, with more organized collagen fibers and enhanced fibroblast proliferation. Gene expression analysis confirmed that QI-CS significantly up-regulated genes associated with extracellular matrix remodeling (MMP-13, MMP-9) and inflammation (IL-1β, TNF-α), further supporting its potential for improved wound healing. These findings suggest that QI-CS has superior therapeutic potential compared to CS, making it a promising candidate for applications in skin creams and inflammation-related conditions.

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Author Biographies

  • Pavan Vijay Kartik, School of Biosciences and Technology, Vellore Institute of Technology, VIT University, Vellore 632014, Tamilnadu, India

    School of Biosciences and Technology, Vellore Institute of Technology, VIT University, Vellore 632014, Tamilnadu, India

  • K. Manigandan, Department of Conservative Dentistry & Endodontics, Sri Ramachandra Dental College, Sri Ramachandra Institute of Higher Education and Research, Chennai 600 116, Tamilnadu, India

    Department of Conservative Dentistry and Endodontics, 
    Sri Ramachandra Dental College and Hospital, Chennai, Tamilnadu

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Published

26-08-2025

Issue

Vol. 39 No. 2 (2025)

Section

Original Research Article

License

Copyright (c) 2025 Pavan Vijay Kartik, R. Mathan Rajan, K. Manigandan, Pratibha Ramani, Ramya Ramadoss, Saheb Ali, Radha Gosala (Author)

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How to Cite

Synergistic Effect of Quercus incana Fruit Extract Incorporated Chitosan in Accelerating Wound Healing and Inflammation Reduction. (2025). Trends in Biomaterials and Artificial Organs, 39(2), 182-187. https://www.biomaterials.org.in/tibao/index.php/tibao/article/view/130

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