Smart Quercetin Delivery: Tailored Sodium Alginate Microbeads for Enhanced Antioxidant and Controlled Degradation

Authors

  • K. Abinaashree Saveetha Medical College, Saveetha Institute of Medical and Technical Institute (SIMATS), Thandalam, Chennai 602105, Tamilnadu, India Author
  • H. Thamizhchelvan Department of Oral Biology, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, Tamilnadu, India Author
  • Jayalakshmi Somasundaram White lab - Material Research Centre, Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Institute (SIMATS), Velappanchavadi, Chennai 600 077, Tamilnadu, India Author
  • Radha Gosala Department of Oral Biology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Institute (SIMATS), Velappanchavadi, Chennai 600077, Tamilnadu, India Author https://orcid.org/0009-0000-8452-8969

Keywords:

sodium alginate, quercetin, drug delivery, antioxidant, degradation

Abstract

Quercetin (Qur), a natural flavonoid exhibiting significant antioxidant, anti-inflammatory, and anti-cancer effects, encounters constraints in clinical use owing to inadequate solubility, diminished bioavailability, and fast metabolism. To address these problems, sodium alginate (Na-Algn), which is biocompatible and biodegradable, has emerged as a viable medium for Qur delivery. This study aims to design and optimize the Qur-loaded Na-Ag microbead carriers, examining the impact of different calcium chloride concentrations on cross-linking density and release patterns of the therapeutic agent. Change of cross-linker and Na-Algn alters the drug encapsulation efficiency (EE %). This approach improves the bioavailability of quercetin (Qur) and stability by utilizing the interaction between Qur, calcium ions, and the alginate matrix, hence extending its therapeutic effects. The degradation, morphological, antioxidant, and in vitro drug release findings indicate that Na-Algn beads serve as versatile and effective vehicles for drug administration, positioning them as attractive options for enhancing the clinical efficacy of bioactive therapeutic agents

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Author Biography

  • Radha Gosala, Department of Oral Biology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Institute (SIMATS), Velappanchavadi, Chennai 600077, Tamilnadu, India

    Assistant Professor, Department of Oral Biology

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Published

26-08-2025

Issue

Vol. 39 No. 2 (2025)

Section

Original Research Article

License

Copyright (c) 2025 K. Abinaashree, H. Thamizhchelvan, Jayalakshmi Somasundaram, Radha Gosala (Author)

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How to Cite

Smart Quercetin Delivery: Tailored Sodium Alginate Microbeads for Enhanced Antioxidant and Controlled Degradation. (2025). Trends in Biomaterials and Artificial Organs, 39(2), 162-167. https://www.biomaterials.org.in/tibao/index.php/tibao/article/view/118

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