Ormocarpum cochinchinense and Glutathione Enhanced Hydroxyapatite for Advanced Bone Graft Applications
Keywords:
bone tissue engineering, glutathione , hydroxyapatiteAbstract
Bone tissue engineering is a promising approach to addressing bone defects and injuries. However, the development of an ideal bone graft with biocompatibility, osteoconductivity, and osteoinductivity remains a challenge. This study aimed to design and characterize a novel bone graft material incorporating hydroxyapatite (HA), Ormocarpum cochinchinese (OC) extract, and glutathione to enhance bioactivity and regenerative potential. Hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), and a composite material containing HA, OC, and glutathione were synthesized. The physicochemical properties of the materials were analyzed using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDAX). The antibacterial and antioxidant activities of the composite were also evaluated. XRD analysis confirmed that the incorporation of OC and glutathione did not significantly alter the crystal structure of HA. FTIR spectra indicated the presence of functional groups from OC and glutathione. SEM revealed a rough and porous surface morphology, which is beneficial for cell attachment and bone regeneration. The composite demonstrated enhanced antibacterial and antioxidant properties, suggesting its potential for improved bone healing. The HA-OC-glutathione composite presents a promising approach for bone graft applications, offering enhanced bioactivity and regenerative capabilities. The synergistic effects of its components contribute to improved osteoconductivity and biocompatibility. Further in vitro and in vivo studies are necessary to assess its clinical potential in bone tissue engineering.
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Copyright (c) 2025 Soundharya Manogaran, H. Tamilselvan, Ramya Ramadoss, Radha Prabhu, K. Hemashree (Author)
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