Recent Advancements in Microfluidic Organ on a Chip Technology: A Short Review

Abstract

An emerging idea known as "Organ-on-a-Chip" has possible applications in the investigation of the physiology and pathophysiology of tissues, including the determination of drug toxicity, and the fabrication of tissue models which could substitute animal experimentation. Organ on a Chip as a significant research platform entered in the current frontier of medical science and drug discovery due to a number of benefits, such as a reduction in sample utilization, improved separating methodology, analytical precision and high-throughput characteristics, flexibility, and reliability. This paper gives an overview on the concept of an organ on a chip and its scientific advancement in the past few years. The review also discusses the primary models developed and utilized for drug discovery and development along with their recent advancement, limitations, and future applications of organ on chip technology.