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The present study was carried out to evaluate the in-vitro biocompatibility of acellular pericardium and diaphragm of caprine and bovine (buffalo) origin, bovine posterior aorta and porcine urinary bladder. They were made acellualr using different protocols and were cross-linked with different cross-linking agents. The crosslinking agents included glutaraldehyde (GA), glyoxal (GO) Diphenyl phosphoryl azide (DPPA), Ethylene glycol diglycidyl ether (EGDGE), polyethylene glycol (PEG), 1-ethyl-3(3-dimethyl aminopropyl) carbbodiimide (EDC) and hexamethylene diiisocyanate (HMDC) and 1,4-butanediol diglycidylether (BDDGE)  for 12,24,48 and 72h. In-vitro studies included the gross observations, non-enzymatic degradation, enzymatic degradation, free protein determination, free amino group determination, fixation index, moisture percent analysis and SDS-PAGE analysis. The results of each biomaterials crosslinked with different agents were presented and discussed on the basis of in-vitro biocompatibilty determination.

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Sharma, N. K., Sharma, A. K., Maiti, S. K., Shrivastava, S., Remya, V., Singh, K., Sonal, S., Devarathnam, J., Dewangan, R., Kumar, A., & Perme, H. (2018). In vitro Determination of Biocompatibility of Acellular Crosslinked Extracellular Matrices Derived from Different Tissue Sources. Trends in Biomaterials & Artificial Organs, 29(1), 3-11. Retrieved from

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