A Comprehensive Review of Graphene-Hydroxyapatite Composites: Promising Biomaterials for Bone Tissue Regeneration
Keywords:
graphene, hydroxyapatite composite, tissue regeneration, biomaterialAbstract
Graphene family materials (GFMs) integrated with hydroxyapatite (HA) stand as compelling biomaterials for bone tissue regeneration, owing to their exceptional mechanical and biological attributes. This comprehensive review elucidates recent strides in research dedicated to the GFMs-HA composite, underscoring its potential as a pivotal biomaterial in the realm of bone tissue regeneration. The discourse herein navigates through discerning analyses of optimal strategies and procedural methodologies imperative for circumventing the proclivity of GFMs toward aggregation within organic, hydrate solutions, and the HA matrix. Emphasis is placed on the significance of biomimetic mineralization as an unobtrusive approach for crafting GFMs-HA composites under mild conditions, and a nuanced exposition of the biomimetic mineralization mechanism governing HA crystal formation in the presence of GFMs is provided. Furthermore, the review expounds upon the salient impact of GFMs-HA composites on cellular behavior, encapsulating pivotal facets such as cell proliferation, adhesion, and their proclivity for stimulating osteogenic differentiation. In addition, an insightful exploration into the augmentation of fracture toughness in HA, consequent to the incorporation of GFMs, is deliberated upon, thereby underscoring the potential translational significance of these composites in the domain of bone tissue engineering. This review serves as a compendium of recent advancements, providing a scholarly perspective on the evolving landscape of GFMs-HA composite research, thereby contributing to the broader discourse on biomaterials for bone tissue regeneration.
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Copyright (c) 2025 othmane khalifi taghzouti (Author)
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