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Abstract

In this study, a new electrospinning method for producing of cycloid fibers has been developed. The cycloid polylactic acid (PLA) fibers produced by this method were then collected (with a 4 mm inner diameter) by a rotational collector as tubular scaffolds for vascular tissue engineering. The morphology, degradation behavior, porosity and mechanical properties of the produced tubular scaffolds were investigated and compared with conventional tubular scaffolds manufactured with random fibers. The results from the tensile tests demonstrated that the mechanical strength and Young module of the prepared scaffolds by cycloid fibers were significantly higher than conventional tubular random fibers. This improvement in the mechanical properties of cycloid fibers justifies the widespread use of these scaffolds in tissue engineering in order to produce more strengthened vessels.

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Author Biography

Masoud Mozafari, Materials and Energy Research Center (MERC)

Masoud Mozafari earned his Ph.D. degree with honorson Biomedical Engineering-Biomaterials from AmirkabirUniversity of Technology, 2013.During 2012–2013, he joined Oklahoma State Universityand Pennsylvania State University as a research associateand research visiting scholar, respectively. Dr. Mozafari’sresearch interests involve the understanding of wholefield of biomaterials with respect to biological interactions,and also delivery systems for potentially useful stem cell and geneticpurposes. He has over 150 pre-reviewed publications as chapterbooks, conference and journal papers. Dr. Mozafari has received severalawards including “Top 10 National Outstanding Scientific Authors” (2011).Dr. Mozafari is currently an assistant professor and head of “BioengineeringResearch Group” in Nanotechnology and Advanced Materials Department,Materials and Energy Research Center (MERC), Tehran, Iran.
How to Cite
Yazdanpanah, A., Amoabediny, G., Shariatpanahi, P., Nourmohammadi, J., Tahmasbi, M., & Mozafari, M. (2014). Synthesis and Characterization of Polylactic Acid Tubular Scaffolds with Improved Mechanical Properties for Vascular Tissue Engineering. Trends in Biomaterials & Artificial Organs, 28(3), 99-105. Retrieved from https://www.biomaterials.org.in/tibao/index.php/tibao/article/view/59