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Abstract

In pharmaceuticals, a turbidity measurement is an essential tool that defines suspended particles in a liquid medium that impacts drug solubility. An elevated level of elemental content may contribute to impurities that lead to drug degradation. The present study aimed to analyze the turbidity and elemental content in solid dispersion and pharmaceutical formulation. Solid dispersion 1 and 2 (SD1 & SD2) prepared with the drug: plasdone: tartaric acid and dug: gelatin, respectively. Nebivolol Hydrochloride was employed as an investigational drug. Sodium and Magnesium content in a pure drug, SD1 & SD2, in an oral-immediate-release drug delivery system (prepared with SD1 &SD2) in tablet formulation (F1 & F2 respectively), was estimated by using an inductively coupled plasma spectrophotometer. Sodium was identified in all samples and found within a specified range. Pure drug & SD1 were identified magnesium-free, while magnesium was observed in SD2, F1 & F2 within the permissible range.

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How to Cite
Shaikh, T., & S., S. (2022). Elemental Content and Turbidity Measurement in Nebivolol Hydrochloride Formulation. Trends in Biomaterials & Artificial Organs, 36(S1), 53-55. Retrieved from https://www.biomaterials.org.in/tibao/index.php/tibao/article/view/583