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The present study was conducted in 18 wistar rats in two equal groups (n=9) to evaluate the wound healing potentiality of xenogenic mesenchymal stem cells for the healing of full thickness skin wound. One 2 X 2 cm2 full thickness wound was created on dorsal region of thorax of adult wistar rats of either sex. Topical application of paraffin gauze over the wound acted as control. The wounds were evaluated based on clinical and macroscopical observation. Gross observations and photographic evaluations were also performed until the end of study. The result suggested that an early granulation tissue formation with reduced exudation and peripheral swelling was observed in the MSC treated group and proved better than control wound. Complete full thickness skin wound healing was observed on day 18-20 with minimum scar in the MSC treated group, whereas, in control group wound healing was completed by day 27- 28. In conclusion, topical transplantation of MSC results in paracrine effects on cellular proliferation and had better wound healing potentiality and MSC appeared as immune-privileged.