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This research aimed to observe clinical condition, implant material density, density of bones around implant, pathological lesion, and histopathology of muscle and bone surrounding implant after the implantation of stainless steel (SS) 316L wire and alternative SS wire. Ten rat strain wistar aged 2-3 months old weighing 200-300 g were divided into two group. Group I (G-I) was implanted by material SS316L wire and Group II (G-II) was implanted by alternative SS wire originally used as fishing line. Radiopaque density of implant material and bone around G-I appeared to decrease. By the new bone growth and bone marrow proliferation were more commonly found in G-II. Tissue cavity, and necrosis was found by the histopathological structure around implant on both groups. Inflammatory cell appeared to be more common in G-II compared to G-I, while connective tissue more common in GI compared to GII. Based on in-vivo test in white rat for 84 days, Group II implanted by alternative wire show better physiological condition compared to Group I implanted by SS316L. Alternative wire has the potential to be used as fixation tool in small animal.


in vivo biocompatibility SS316L alternative SS fixation

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Erwin, E., Etriwati, E., Rusli, R., Amiruddin, A., Karmil, T. F., Masyitah, D., & Yudistira, Y. (2021). Evaluation of SS316L Wire and Alternative SS Wire Usage as Internal Fixation for Fracture: An In-vivo Comparative Study in Rat. Trends in Biomaterials & Artificial Organs, 35(4), 370-375. Retrieved from

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