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Coronavirus disease 2019 or COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2 (previously named as 2019-nCoV) that emerged in Wuhan, China. The efficient transmission of this novel virus enabled it to spread across the globe at a very high rate. In order to overcome current pandemic situation, it is necessary to develop specific therapeutic drugs and vaccines for COVID-19. Therefore, the establishment of an efficient animal model can help to accelerate the process of pre-clinical studies. We have to select animal models based on our previous experience with SARS-CoV research. Preliminary findings indicate that the animal species having ACE2 receptor with close similarity to the human beings are ideal to be used for the purpose. Animal models can help us to study the transmission, pathogenesis, pathophysiology, and immune-responses associated with SARS-CoV-2 infection. This can further fuel our need for developing vaccine and therapeutics against SARS-CoV-2 in the coming future.


COVID-19 SARS-CoV-2 animal model therapeutics vaccine development transgenic mice

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Faslu Rahman , C., Sharun, K., Jose, B. ., Sivaprasad, M., & Jisna, K. (2020). Animal Models for SARS-CoV-2 Infection: A Tool for Vaccine and Therapeutic Research. Trends in Biomaterials & Artificial Organs, 34(S3), 78-82. Retrieved from