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The most remarkable smallest known pathogens are the viruses that cause notable losses in human health. Their infectious nature is one of the main reasons for the probable health impacts. The COVID-19 crisis that is presently affecting all countries around the world is a true testament to the characteristic nature of a virus. We have already seen the disastrous nature of this virus affecting millions of people and its capacity to ruin the global economy. So, the rush of the hour is to find prompt diagnosis and effective treatment for achieving virus control and its total elimination. The current development of nanomaterials with its unique features and functions has brought out a chain of applications and technologies that could curb this crisis. In this article, we will review the literature already existing and provide a summary of the current developments of nanoparticles proposed that are presently under extensive research and clinical trials that are predicted to considerably improve the COVID-19 crisis.