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Eggshells are an attractive natural source for the preparation of hydroxyapatite (HA) bone substitute and drug carrier. Eggshells also contain trace elements such as Mg, Na, Si etc., essential for biomineralization. Hence, the selectivity of eggshell derived calcium deficient HA (ECDHA) nanoparticles for protein and drug delivery was studied. ECDHA with a Ca/P molar ratio of 1.5 was prepared and release studies of antibiotics, an anti-inflammatory drug, and bovine serum albumin (BSA) protein were evaluated. ECDHA carriers were found to have a selective preference for antibiotics loading and BSA delivery compared to synthetic samples. ECDHA thus seem to have an optimal composition for the delivery of antibiotics and protein for bone regenerative applications.