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Twenty clinically healthy adult New Zealand white rabbits of either sex were randomly divided into three groups (I, II and III). Group I and II consisted of eight animals each and in the control group (III) having four animals. Under ketamine (44mg/kg, IM) and xylazine (5 mg/kg, IM) anaesthesia a full thickness abdominal wall defect (2x3 cm) was created and   immediately repaired with 0.5% glutaraldehyde treated bovine pericardium in groups I and II. In control group the defect was repaired by autograft. In group II ultrasound therapy was given at the repair site from day 3 postoperative at the rate of 0.5 watt/cm2 for 5 minutes for two weeks on alternate day. The grafts were very well taken up by host without any immune reaction. Ultrasound therapy reduced the adhesions in group II. Hexosamine level reduced in all the groups at day 21. Collagen, hydroxyproline and elastin increased at day 21. Changes in zinc and copper was statistically non significant. Normal inflammatory cellular reaction was seen in all groups. The healing was seen without any complication in all groups.


glutaraldehyde, bovine pericardium, ultrasound therapy, rabbit

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Author Biography

Naveen Kumar, Indian Veterinary Research Institute

Principal Scientist, Division of Surgery, Indian Veterinary Research Institute, Izatnagar-243122, Bareilly (U.P.)

How to Cite
Kumar, N. (2021). Glutaraldehyde Crosslinked Bovine Pericardium with and without Ultrasound Therapy for Reconstruction of Abdominal Wall Defects in Rabbits. Trends in Biomaterials & Artificial Organs, 35(1), 1-9. Retrieved from

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