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The current preventive strategy for dental caries is the use of dentifrices containing calcium phosphates, which provide additional calcium and phosphate ions to revert the enamel subsurface demineralisation. It has been identified that nano-hydroxyapatite materials are more effective for this application.  In this work, a dentifrice containing an optimised nano-calcium strontium apatite (Calstrotite 25) has been developed aiming at better performance.  This has been subjected to acceptance tests as per standard. The enamel remineralisation potential of the new dentifrice has been evaluated in vitro by a pH cycling model, simulating the natural demineralisation-remineralisation process. The enamel specimens were divided into 3 groups of 6 numbers each. Group 1, along with other groups, was subjected to demineralizing cycle.  Group 2 was further subjected to remineralizing cycle and Group 3 was brushed with the new dentifrice, in addition to the remineralizing cycle. Energy dispersive analysis (EDS) was employed to assess the change in mineral concentration at the subsurface regions by sectioning the specimens.

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Varghese, A. G., Adarsh, R., Nishad, K., & Komath, M. (2019). In vitro Evaluation of the Enamel Remineralization Potential of a Dentifrice Containing Nano Calcium Strontium Apatite. Trends in Biomaterials & Artificial Organs, 33(3), 56-63. Retrieved from