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Collagenous extracellular matrix (ECM) based biomaterials have an established place as medical devices for wound regeneration. In the search for biomaterials we have compared caprine forestomach matrices (CFM), from all three components of forestomach on the basis of biochemically diversity and biological functional ability. CFM was decellularized using a chemical process that was shown to reduce the cellularity of the ECM and aid tissue delamination. OFM produced using this technique was shown to retain residual basement membrane components, as evidence by the histology. The collagenous microarchitecture of OFM retained many components of native ECM including fibronectin, glycosaminoglycans, elastin and fibroblast growth factor basic. OFM was non-toxic to mammalian cells and supported fibroblast and keratinocyte migration, differentiation and infiltration. CFM is a culturally acceptable alternative to current collagen-based biomaterials and has immediate clinical applications in wound healing and tissue regeneration.