A Comprehensive Review on Role of Nanotechnology in Drug Delivery System
DOI:
https://doi.org/10.65795/rmhy7312Keywords:
nanotechnology, drug delivery systems, targeted drug delivery, controlled drug release, nanocarriersAbstract
Nanotechnology has become a revolutionary technology in contemporary medicine that can provide new solutions to the inefficiency of the traditional drug delivery systems. Nanoscale properties enable precise drug targeting, controlled release, enhanced bioavailability, and reduced systemic toxicity. The review gives a general description of drug delivery systems that are based on nanotechnology, with liposomes, polymeric nanoparticles, dendrimers, solid lipid nanoparticles, and metallic nanoparticles being the main examples of nanocarriers. Critical discussions are made of their design strategies, drug loading capacities, release mechanisms and therapeutic advantages. In addition, more recent technological developments in the areas of targeted delivery, such as ligand-mediated delivery and stimuli-responsive systems, are discussed in the treatment of various diseases in cancer, infections, and neurological conditions. Despite significant advancements, there are still issues of toxicity, stability, large-scale production, and regulatory issues, which are impediments to clinical translation. In general, the field of nanotechnology offers a potential platform in improving therapeutic efficacy and development of biomaterial-based medical applications.
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References
Mir M, Ishtiaq S, Rabia S, Khatoon M, Zeb A, Khan GM, et al. Nanotechnology: from In Vivo Imaging System to Controlled Drug Delivery. Nanoscale Res Lett 2017;12:500. DOI: https://doi.org/10.1186/s11671-017-2249-8
Sahu T, Ratre YK, Chauhan S, Bhaskar LVKS, Nair MP, Verma HK. Nanotechnology based drug delivery system: Current strategies and emerging therapeutic potential for medical science. J Drug Deliv Sci Technol 2021;63:102487. DOI: https://doi.org/10.1016/j.jddst.2021.102487
Afzal O, Altamimi ASA, Nadeem MS, Alzarea SI, Almalki WH, Tariq A, et al. Nanoparticles in Drug Delivery: From History to Therapeutic Applications. Nanomaterials 2022;12:4494. DOI: https://doi.org/10.3390/nano12244494
Sim S, Wong N. Nanotechnology and its use in imaging and drug delivery (Review). Biomed Rep 2021;14:42. DOI: https://doi.org/10.3892/br.2021.1418
Kuskov AN, Kukovyakina E V. Nanotechnology-Based Drug Delivery Systems, 2nd Edition. Pharmaceutics 2025;17:110. DOI: https://doi.org/10.3390/pharmaceutics17010110
Sun L, Liu H, Ye Y, Lei Y, Islam R, Tan S, et al. Smart nanoparticles for cancer therapy. Signal Transduct Target Ther 2023;8:418. DOI: https://doi.org/10.1038/s41392-023-01642-x
Parvin N, Aslam M, Alam MN, Mandal TK. Nanotechnology Driven Innovations in Modern Pharmaceutics: Therapeutics, Imaging, and Regeneration. Nanomaterials 2025;15:1733. DOI: https://doi.org/10.3390/nano15221733
Islam S, Ahmed MMS, Islam MA, Hossain N, Chowdhury MA. Advances in nanoparticles in targeted drug delivery–A review. Results in Surfaces and Interfaces 2025;19:100529. DOI: https://doi.org/10.1016/j.rsurfi.2025.100529
Sharma S, Kumar M, Gautam A, Palanisamy S, Sharma A. Metallic Nanoparticles, Carbon-Based Nanocomposites for Drug Delivery System, 2025, p. 495–521. DOI: https://doi.org/10.1007/978-981-97-8086-0_17
Guimarães D, Cavaco-Paulo A, Nogueira E. Design of liposomes as drug delivery system for therapeutic applications. Int J Pharm 2021;601:120571. DOI: https://doi.org/10.1016/j.ijpharm.2021.120571
Rizvi SAA, Saleh AM. Applications of nanoparticle systems in drug delivery technology. Saudi Pharmaceutical Journal 2018;26:64–70. DOI: https://doi.org/10.1016/j.jsps.2017.10.012
Taher M, Susanti D, Haris MS, Rushdan AA, Widodo RT, Syukri Y, et al. PEGylated liposomes enhance the effect of cytotoxic drug: A review. Heliyon 2023;9:e13823. DOI: https://doi.org/10.1016/j.heliyon.2023.e13823
Su S, Kang PM. Systemic Review of Biodegradable Nanomaterials in Nanomedicine. Nanomaterials 2020;10:656. DOI: https://doi.org/10.3390/nano10040656
Zhu Y, Liu C, Pang Z. Dendrimer-Based Drug Delivery Systems for Brain Targeting. Biomolecules 2019;9:790. DOI: https://doi.org/10.3390/biom9120790
Yan X, Chen Q. Polyamidoamine Dendrimers: Brain-Targeted Drug Delivery Systems in Glioma Therapy. Polymers (Basel) 2024;16:2022. DOI: https://doi.org/10.3390/polym16142022
Fadaei MR, Fadaei MS, Kheirieh AE, Hatami H, Rahmanian-Devin P, Tayebi-Khorrami V, et al. Overview of dendrimers as promising drug delivery systems with insight into anticancer and anti-microbial applications. Int J Pharm X 2025;10:100390. DOI: https://doi.org/10.1016/j.ijpx.2025.100390
Duan Y, Dhar A, Patel C, Khimani M, Neogi S, Sharma P, et al. A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems. RSC Adv 2020;10:26777–91. DOI: https://doi.org/10.1039/D0RA03491F
Rabiee N, Ahmadi S, Akhavan O, Luque R. Silver and Gold Nanoparticles for Antimicrobial Purposes against Multi-Drug Resistance Bacteria. Materials 2022;15:1799. DOI: https://doi.org/10.3390/ma15051799
Abdelkawi A, Slim A, Zinoune Z, Pathak Y. Surface Modification of Metallic Nanoparticles for Targeting Drugs. Coatings 2023;13:1660. DOI: https://doi.org/10.3390/coatings13091660
Jayaprakash N, Elumalai K, Manickam S, Bakthavatchalam G, Tamilselvan P. Carbon nanomaterials: Revolutionizing biomedical applications with promising potential. Nano Materials Science 2024.
Liang J, Wu Y, Zhang C, Yi R, Zheng J, Zhao R, et al. Graphene-Based Nanomaterials in Photodynamic Therapy: Synthesis Strategies, Functional Roles, and Clinical Translation for Tumor Treatment. Int J Nanomedicine 2025;Volume 20:8359–92. DOI: https://doi.org/10.2147/IJN.S516606
Giri PM, Banerjee A, Layek B. A Recent Review on Cancer Nanomedicine. Cancers (Basel) 2023;15:2256. DOI: https://doi.org/10.3390/cancers15082256
Lv Y, Li W, Liao W, Jiang H, Liu Y, Cao J, et al. Nano-Drug Delivery Systems Based on Natural Products. Int J Nanomedicine 2024;Volume 19:541–69. DOI: https://doi.org/10.2147/IJN.S443692
Preeti, Sambhakar S, Malik R, Bhatia S, Al Harrasi A, Rani C, et al. Nanoemulsion: An Emerging Novel Technology for Improving the Bioavailability of Drugs. Scientifica (Cairo) 2023;2023:1–25. DOI: https://doi.org/10.1155/2023/6640103
Sairam AB, Sanmugam A, Pushparaj A, Mahesh Kumar G, Sundarapandian N, Balaji S, et al. Toxicity of Polymeric Nanodrugs as Drug Carriers. ACS Chemical Health & Safety 2023;30:236–50. DOI: https://doi.org/10.1021/acs.chas.3c00008
Srivastava A, Ahmad A, Siddiqui S, Islam A. Innovations in targeted drug delivery: From nanotechnology to clinical applications. Next Nanotechnology 2026;9:100336. DOI: https://doi.org/10.1016/j.nxnano.2025.100336
Liu Y, Si L, Jiang Y, Jiang S, Zhang X, Li S, et al. Design of pH-Responsive Nanomaterials Based on the Tumor Microenvironment. Int J Nanomedicine 2025;Volume 20:705–21. DOI: https://doi.org/10.2147/IJN.S504629
AlSawaftah NM, Awad NS, Pitt WG, Husseini GA. pH-Responsive Nanocarriers in Cancer Therapy. Polymers (Basel) 2022;14:936. DOI: https://doi.org/10.3390/polym14050936
Lan H-R, Zhang Y-N, Han Y-J, Yao S-Y, Yang M-X, Xu X-G, et al. Multifunctional nanocarriers for targeted drug delivery and diagnostic applications of lymph nodes metastasis: a review of recent trends and future perspectives. J Nanobiotechnology 2023;21:247. DOI: https://doi.org/10.1186/s12951-023-01990-4
Bazak R, Houri M, El Achy S, Kamel S, Refaat T. Cancer active targeting by nanoparticles: a comprehensive review of literature. J Cancer Res Clin Oncol 2015;141:769–84. DOI: https://doi.org/10.1007/s00432-014-1767-3
Sung Y, Choi Y, Kim ES, Ryu JH, Kwon IC. Receptor-ligand interactions for optimized endocytosis in targeted therapies. Journal of Controlled Release 2025;380:524–38. DOI: https://doi.org/10.1016/j.jconrel.2025.01.060
Spoială A, Ilie C-I, Motelica L, Ficai D, Semenescu A, Oprea O-C, et al. Smart Magnetic Drug Delivery Systems for the Treatment of Cancer. Nanomaterials 2023;13:876. DOI: https://doi.org/10.3390/nano13050876
Anjum S, Ishaque S, Fatima H, Farooq W, Hano C, Abbasi BH, et al. Emerging Applications of Nanotechnology in Healthcare Systems: Grand Challenges and Perspectives. Pharmaceuticals 2021;14:707. DOI: https://doi.org/10.3390/ph14080707
Deivayanai VC, Thamarai P, Karishma S, Saravanan A, Yaashikaa PR, Vickram AS, et al. Advances in nanoparticle-mediated cancer therapeutics: Current research and future perspectives. Cancer Pathogenesis and Therapy 2025;3:293–308. DOI: https://doi.org/10.1016/j.cpt.2024.11.002
Li G, Wang C, Jin B, Sun T, Sun K, Wang S, et al. Advances in smart nanotechnology-supported photodynamic therapy for cancer. Cell Death Discov 2024;10:466. DOI: https://doi.org/10.1038/s41420-024-02236-4
Kochman U, Sitka H, Kuźniar J, Czaja M, Kozubek P, Beszłej JA, et al. Targeted Nanoparticles for Drug Delivery Across the Blood–Brain Barrier in Early and Late Stages of Alzheimer’s Disease: A Review. Mol Neurobiol 2026;63:75. DOI: https://doi.org/10.1007/s12035-025-05417-z
Wang N, Ni C, Jiang Q, Shi X, Guo R. Recent Advances in Targeted and Microenvironment-Responsive Drug Delivery Nanoplatforms for Atherosclerosis Therapy. Precision Medicine and Engineering 2026:100065. DOI: https://doi.org/10.1016/j.preme.2026.100065
Ahmed N, Abusalah M, Abuarqoub A. Nanomedicine in the Fight Against Multidrug-Resistant Infections: A Review on Emerging Strategies and Translational Prospects. Int J Nanomedicine 2025;Volume 20:12331–62. DOI: https://doi.org/10.2147/IJN.S547259
Nunes R, Valente JFA, Patrício TMF, Sousa Â. Nanoengineered innovations on DNA delivery systems for targeted cancer therapy. J Drug Deliv Sci Technol 2025;111:107131. DOI: https://doi.org/10.1016/j.jddst.2025.107131
Li J, Wang Q, Xia G, Adilijiang N, Li Y, Hou Z, et al. Recent Advances in Targeted Drug Delivery Strategy for Enhancing Oncotherapy. Pharmaceutics 2023;15:2233. DOI: https://doi.org/10.3390/pharmaceutics15092233
Desai N, Rana D, Patel M, Bajwa N, Prasad R, Vora LK. Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape. Small 2025;21. DOI: https://doi.org/10.1002/smll.202502315
Herdiana Y. Bridging the Gap: The Role of Advanced Formulation Strategies in the Clinical Translation of Nanoparticle-Based Drug Delivery Systems. Int J Nanomedicine 2025;Volume 20:13039–53. DOI: https://doi.org/10.2147/IJN.S554821
Nyabadza A, McCarthy É, Makhesana M, Heidarinassab S, Plouze A, Vazquez M, et al. A review of physical, chemical and biological synthesis methods of bimetallic nanoparticles and applications in sensing, water treatment, biomedicine, catalysis and hydrogen storage. Adv Colloid Interface Sci 2023;321:103010. DOI: https://doi.org/10.1016/j.cis.2023.103010
Hossen S, Hossain MK, Basher MK, Mia MNH, Rahman MT, Uddin MJ. Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review. J Adv Res 2019;15:1–18. DOI: https://doi.org/10.1016/j.jare.2018.06.005
Lionadi I, Payam AF. Nanotechnology in Cancer Therapy: How Nanoparticles Are Shaping the Future of Personalized Treatment. ACS Nano Medicine 2026. DOI: https://doi.org/10.1021/acsnanomed.5c00117
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Copyright (c) 2026 Shalini Tiwari, Shreya Kotnala, Rohinee Bhandari, Ashutosh Semwal, Rishabh Vats, Diksha Singh, Diksha Rawat, Arunima Nayak, Brij Bhushan (Author)

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Accepted 14-07-2026
Published 30-07-2026


