Injectable and Self-healing Carbohydrate-based Hydrogel for Protein Delivery

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Ik Sung Cho Tooru Ooya

Abstract

This work is focused on the development of a new injectable and self-healing drug delivery system for proteins sustained release. A series of injectable self-healing hydrogels derived from oxidized dextran (Odex) and glycol chitosan (GC) were prepared by Schiff base reaction. Odex was prepared by cleaving the dextran with sodium
periodate. The gelation readily took place at physiological pH and temperature. The gelation time, mechanical properties, water content, in vitro degradation, self-healing properties and protein release profile were investigated. The in vitro cytotoxicity studies showed that the Odex and GC were non-cytotoxic. Therefore, these injectable
self-healing hydrogels are expected to be a promising biomaterial for drug delivery system and various biomedical applications.

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Original Research Articles