Synthesis and Characterization of Antihyperglycemic Drug Delivery Applications of Certain Xylitol Based Copolyester

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K. Deepa Jai Sankar Viswanathan

Abstract

Xylitol based triblock polyesters have emerged as a promising family of biomaterials for implants, drug delivery and tissue engineering applications. In this present investigation, xylitol with citric acid and suberic acid were synthesised by catalyst free melt polycondensation reaction. The synthesized pre-polymers were characterized by solubility studies, inherent viscosity and Fourier Transform Infrared (FTIR) spectroscopy. The molecular weight of the prepolymer was determined by Gel Permeation Chromatography (GPC). The chemical structures of synthesized polymers were confirmed by 1H-NMR and 13C-NMR spectroscopy. The glass transition (Tg) and melting temperature (Tm) of polymer were studied by Differential Scanning Calorimetry (DSC). The mechanical properties and tensile strength was evaluated by Universal Testing Machine (UTM) and in vitro degradation of polymer in both phosphate buffer saline (PBS) and sodium hydroxide (NaOH) solution were examined. The drug delivery applications of the synthesised xylitol based copolyester are studied. The synthesised copolyesters were doped with antidiabetic drug and variation in drug release behavior was studied by UV-visible spectrophotometer.

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